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Target intelligence / Profile preview
Fibroblast Growth Factor Receptor Family (FGFR)
- Target
- FGFR
- Molecular classification
- Receptor, Receptor Tyrosine Kinase
01
Overview
The fibroblast growth factor receptor (FGFR) family is a group of receptor tyrosine kinases that play essential roles in cell signaling, development, tissue homeostasis, and disease. The family consists of four main members: FGFR1, FGFR2, FGFR3, and FGFR4. A fifth member (FGFR5) has been identified but lacks the intracellular kinase domain present in the others. FGFRs bind to fibroblast growth factors (FGFs), and upon ligand binding, dimerize and transautophosphorylate, initiating downstream signaling cascades involved in proliferation, differentiation, migration, survival, angiogenesis, and metabolic regulation. Dysregulation or mutation of FGFR genes is implicated in various diseases, including cancers and congenital disorders.
- Other names
- FGFR1FGFR2FGFR3FGFR4FGFR5
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Cell signalingDevelopmentTissue homeostasisCell proliferationCell differentiationCell migrationCell survivalAngiogenesisMetabolic regulationEmbryonic developmentTissue patterningOrganogenesisWound healingBone growthMetabolism regulation
04
Disease associations
CancerUrothelial carcinomaHepatocellular carcinomaOvarian cancerLung adenocarcinomaAchondroplasiaCongenital disorders
05
Safety considerations
Adverse effects associated with FGFR inhibitors
06
Interacting drugs
Erdafitinib
2 more in the full profile.
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