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Target intelligence / Profile preview
Fibroblast Growth Factor Receptors (Pan-FGFR) (Pan-FGFR)
- Target
- Pan-FGFR
- Molecular classification
- Receptor, Receptor Tyrosine Kinase
01
Overview
Fibroblast growth factor receptors (FGFRs) are a family of receptor tyrosine kinases that play essential roles in cell signaling, development, and disease. "Pan-FGFR" refers to agents or analyses that target or consider all four main FGFR family members: FGFR1, FGFR2, FGFR3, and FGFR4. Dysregulation of FGFR signaling is implicated in various cancers, making them a therapeutic target. Pan-FGFR inhibitors show efficacy against tumors harboring activating genomic changes but may be associated with resistance mechanisms.
- Other names
- FGFR1/2/3/4FGFR familyPan-fibroblast growth factor receptor
02
Mechanism of action
Small molecules inhibiting kinase activity across multiple FGFR family members.
03
Biological functions
Cell proliferationDifferentiationMigrationAngiogenesisMetabolismSignal transduction
04
Disease associations
CancerUrothelial carcinomaHepatocellular carcinomaOvarian cancerLung adenocarcinomaSkeletal dysplasiaDevelopmental disorders
05
Safety considerations
Resistance mechanismsSpecific toxicities related to pan-FGFR inhibition
06
Interacting drugs
Erdafitinib
1 more in the full profile.
07
Biomarkers
FGFR3 mutations (urothelial carcinoma)FGFR2 rearrangements (intrahepatic cholangiocarcinoma)FGFR1 mutations (glioma)FGFR alterations (various cancers)
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