Fibroblast growth factor signaling pathway (FGF signaling pathway)

The fibroblast growth factor signaling pathway regulates diverse cellular processes including proliferation, migration, differentiation, and survival through the interaction of fibroblast growth factors (FGFs) with fibroblast growth factor receptors (FGFRs), which are receptor tyrosine kinases[1][4][3]. Activation of FGFRs triggers major signaling cascades such as the RAS/MAP kinase, PI3K/AKT, and PLCγ pathways[1]. Dysregulation is implicated in multiple diseases, particularly cancer and developmental syndromes[1][3][6]. Therapeutic strategies target specific FGFR isoforms or critical downstream nodes, rather than the entire pathway[1][3].

Other names

FGF pathwayFGFR signalingFGF/FGFR axis

Drugs targeting the FGF signaling pathway (specifically FGFRs) primarily work by inhibiting receptor tyrosine kinase activity, which can involve downregulation or blocking of FGF-FGFR binding, and subsequently blocking downstream signaling cascades such as the RAS/MAP kinase or PI3K/AKT pathways.