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Target intelligence / Profile preview
Fibroblasts
- Molecular classification
- Mesenchymal cell
01
Overview
Fibroblasts are mesenchymal cells responsible for producing extracellular matrix (ECM) proteins, including collagens. In the pleura, they play a key role in tissue repair and fibrosis. Upon injury or inflammation, they are activated by growth factors like TGF-β1 to proliferate and synthesize collagen, especially type I. Excessive activation leads to pleural thickening and impaired gas exchange. Myofibroblasts are an activated form of fibroblasts with enhanced contractility and synthetic activity.
- Other names
- MyofibroblastsPleural fibroblastsLung fibroblasts
02
Mechanism of action
N/A - Cell type, not a specific molecule
03
Biological functions
ECM synthesisCollagen synthesisTissue repairWound healing
04
Disease associations
Pleural fibrosisPulmonary fibrosisChronic inflammation
05
Safety considerations
Non-specific targeting could impair wound healing
06
Biomarkers
FSP-1 (for myofibroblasts)
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