Fibroinflammatory states

“Fibroinflammatory states” is an umbrella, non-molecular term referring to conditions characterized by concurrent or linked fibrosis (excess extracellular matrix deposition and scarring driven by activated fibroblasts) and inflammation across organs and diseases. It encompasses processes such as pulmonary fibrosis and systemic entities like IgG4-related disease, and it is also used analytically to describe tumor subtypes with high inflammatory signaling and distinct immunosuppressive microenvironments. Because it is not a single molecule, receptor, enzyme, or gene product, it is not considered a therapeutic target per se; management typically focuses on the underlying disease mechanism (e.g., antifibrotics in pulmonary fibrosis, corticosteroids/immunomodulators in IgG4-related disease, or immunotherapy strategies in inflammation-defined tumor subtypes).

Other names

Fibro-inflammatory statesFibroinflammationFibroinflammatory disease spectrumFibrosis and inflammation