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Fibronectin (None)

Target: None
Molecular classification: Extracellular Matrix Protein, Glycoprotein

Overview

Fibronectin is a high-molecular-weight glycoprotein found in the extracellular matrix (ECM) and blood plasma. It exists primarily as a dimer and plays critical roles in cell adhesion, cell growth, cell migration, differentiation, and actin dynamics. These functions are essential for processes such as wound healing and embryonic development. Altered expression or organization of fibronectin has been associated with several diseases including cancer, arthritis, and fibrosis.

Biological functions

Cell adhesionCell growthCell migrationDifferentiationActin dynamicsWound healingEmbryonic developmentOpsonizationMaintenance of cell shapeClot stabilizationNerve regenerationOsteoblast mineralizationRegulation of type I collagen deposition

Disease associations

CancerArthritisFibrosisWound healing defectsEmbryonic development defects

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