Fibronectin 1 mRNA (FN1 mRNA) (FN1 mRNA)

Fibronectin 1 (FN1) mRNA is the transcript responsible for the synthesis of fibronectin, a high-molecular-weight glycoprotein essential for the assembly of the extracellular matrix (ECM) [1]. This molecule exists in multiple isoforms generated by alternative splicing, playing pivotal roles in cell adhesion, migration, and tissue morphogenesis [1, 2]. In the context of disease, the dysregulation of FN1 mRNA expression is a primary driver of pathological fibrosis in organs such as the liver, kidneys, and lungs, where excessive fibronectin deposition leads to organ dysfunction [3]. Furthermore, FN1 is a well-recognized marker and driver of the epithelial-mesenchymal transition (EMT) in various cancers, facilitating tumor progression and metastasis [4]. Therapeutic interventions targeting FN1 mRNA, including antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs), are being explored to selectively downregulate fibronectin production in fibrotic and oncogenic environments [5, 6]. However, because fibronectin is vital for normal physiological processes like wound healing and vascular stability, precise delivery and dosing are critical to avoid adverse systemic effects [7]. Sources: [1] UniProt Consortium. Fibronectin (P02751). [2] Pankov, R., & Yamada, K. M. (2002). Fibronectin at a glance. Journal of Cell Science. [3] Valiente-Alandi, I., et al. (2018). Fibronectin is required for repair and remodeling after myocardial infarction. Circulation. [4] Wang, J. P., et al. (2017). Fibronectin promotes cell growth and migration in colorectal cancer. World Journal of Gastroenterology. [5] Zhou, X., et al. (2015). siRNA-mediated knockdown of fibronectin 1 inhibits the proliferation and invasion of colorectal cancer cells. Oncology Reports. [6] Yazdani, S., et al. (2017). Target gene inhibition by antisense oligonucleotides in fibrosis. Advanced Drug Delivery Reviews. [7] Lenselink, E. A. (2015). The Role of Fibronectin in Normal Wound Healing. International Wound Journal.

Other names

FN1FNCIGCold-insoluble globulinLETSMSFFINC

RNA interference (RNAi) and RNase H-mediated degradation of target mRNA