Fibronectin-binding protein (FnBP)

Fibronectin-binding proteins (FnBPs) are a class of microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) primarily found in Gram-positive bacteria like Staphylococcus aureus (Source: UniProt P0C0L5). These proteins mediate the critical first step of infection by binding to host fibronectin, facilitating bacterial attachment to the extracellular matrix and subsequent colonization (Source: PMID: 12730535). Beyond simple adhesion, FnBPs can induce the internalization of bacteria into host cells, such as endothelial cells and osteoblasts, which allows the pathogen to evade the immune system and persist in tissues (Source: PMID: 24103447). This mechanism is central to the development of chronic infections, including endocarditis, osteomyelitis, and prosthetic joint infections (Source: StatPearls). As therapeutic targets, FnBPs are being explored for anti-adhesion strategies, where inhibitors like the pUR4 peptide or specific antibodies aim to block the binding interface and prevent the initiation of disease (Source: PMID: 24103447). These approaches are particularly relevant in the context of rising antibiotic resistance, as they target virulence factors rather than essential growth pathways.

Other names

Fibronectin-binding partnersFnBPsMSCRAMMsFibronectin-binding adhesinsFnbpAFnbpBSfbI

Competitive inhibition of the bacterial binding domain to host fibronectin, preventing adhesion and internalization [PMID: 24103447].