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Target intelligence / Profile preview
Fibronectin Extra-Domain B (EDB-FN)
- Target
- EDB-FN
- Molecular classification
- Extracellular matrix glycoprotein, Fibronectin isoform
01
Overview
Fibronectin extra-domain B (EDB-FN) is a specialized splice variant of fibronectin with critical roles in embryonic development and pathological processes like cancer progression. Its selective overexpression within tumor vasculature makes it both a valuable biomarker for malignancy detection/imaging and an attractive candidate for targeted therapies—including antibody-drug conjugates or engineered immune cells—though further research continues into optimizing these approaches given complex interactions within the tumor microenvironment.
- Other names
- Extra-Domain B FibronectinEIIIBED-B FibronectinOncofetal Fibronectin
02
Mechanism of action
Targeted drug delivery to tumors; CAR T-cell therapy target
03
Biological functions
Angiogenesis supportECM assemblyCell adhesionCell migrationTube formationEndothelial cell proliferationNeovascularization
04
Disease associations
CancerWound healingTumorigenesisAngiogenesis
05
Safety considerations
Tumor microenvironment factors affecting CAR T-cell efficacyPotential off-target effects if expression not strictly limited to tumor tissues
06
Biomarkers
EDB-FN expression in tumor vasculatureEDB-FN expression in cancer cells
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