Fibronectin leucine-rich transmembrane protein 3 (FLRT3)

Fibronectin leucine-rich transmembrane protein 3 (FLRT3) is a member of the FLRT family involved in cell adhesion and receptor signaling, with structural similarity to small leucine-rich proteoglycans found in the extracellular matrix[1][2][3][5]. FLRT3 plays key roles during embryonic development and in the adult, notably in the nervous system as a postsynaptic ligand for latrophilin receptors, where it is important for excitatory synapse formation[1][3]. It also modulates intercellular adhesion, neuronal migration, axon guidance (acting as a co-receptor with Robo1 for Netrin-1), and participates in FGF signaling by interacting with FGFR1, regulating tissue morphogenesis such as heart and craniofacial development[1][3]. FLRT3 is expressed in numerous tissues and has been implicated in pathologies including cancer—where it may help tumor cells evade immune detection—and genetic disorders such as high myopia and hypogonadotropic hypogonadism[1][3][5].

Other names

FLRT3Leucine-rich repeat transmembrane protein FLRT3KIAA1469UNQ856/PRO1865Fibronectin-like domain-containing leucine-rich transmembrane protein 3HH21mKIAA14695530600M07RIKC430047I10RIKRGD1566005