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Target intelligence / Profile preview
Integrin α5β1 (α5β1)
- Target
- α5β1
- Molecular classification
- Receptor, Integrin, Transmembrane protein
01
Overview
Integrin α5β1, also known as the fibronectin receptor or VLA-5, is a transmembrane heterodimeric protein composed of alpha 5 (ITGA5/CD49e) and beta 1 (ITGB1/CD29) subunits. It is a primary cellular receptor for fibronectin, an essential extracellular matrix (ECM) glycoprotein. It plays critical roles in cell adhesion, migration, and angiogenesis, and is often overexpressed in tumors and tumor vasculature, making it a potential therapeutic target.
- Other names
- Fibronectin receptorVLA-5CD49e/CD29 complex
02
Mechanism of action
Blocking ligand binding; Disrupting downstream signaling pathways
03
Biological functions
Cell adhesionCell migrationAngiogenesisSignal transductionECM interactions
04
Disease associations
Cancer progressionTumor angiogenesis
05
Safety considerations
Potential off-target effectsResistance mechanisms
06
Biomarkers
Expression level in tumor tissueExpression level in tumor vasculature
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