Fibronectin type III domain-containing protein 1 (FNDC1)

Fibronectin type III domain-containing protein 1 (FNDC1) is a secreted protein—classified as a myokine—that plays a key regulatory role in skeletal muscle differentiation, regeneration, and repair[1]. FNDC1 contains four conserved fibronectin type III domains and one tegument UL36 (PHA03247) domain. It is secreted by myoblasts during myogenesis and after muscle injury. FNDC1 promotes myoblast differentiation and myofiber formation by directly binding to integrin α5β1, which activates the FAK/PI3K/AKT/mTOR pathway, driving muscle growth and regeneration. Recombinant, truncated FNDC1 (FN3 domain) has been shown to ameliorate muscle degeneration and improve function in muscular dystrophy models[1]. FNDC1 has also been implicated in cardiac muscle cell apoptosis, hypoxia responses, and is associated with several cancers and non-muscle diseases. No interacting drugs are currently reported, but its mechanisms of signal transduction, tissue specificity, and large size are relevant when considering therapeutic development[1][2][3][4].

Other names

AGS8FNDC2MEL4B3BA243O10.1DJ322A24.1KIAA1866dJ322A24.1Activation-associated cDNA proteinExpressed in synovial lining proteinbA243O10.1

Agonist/activation of integrin α5β1; Activation of FAK/PI3K/AKT/mTOR signaling pathway[1]