Fibronectin type III domain-containing protein 8 (FNDC8)

Fibronectin type III domain-containing protein 8 (FNDC8) is a protein-coding gene belonging to the FNDC family, distinguished by the presence of one or more fibronectin type III domains, typically implicated in protein-protein interactions and structural functions in cells[3][6]. FNDC8 is highly expressed in the testis and is specifically localized to the perinuclear theca of developing and mature spermatozoa, where it interacts with notable structural proteins such as CCIN and ACTL7A, playing an essential role in sperm head shaping and proper acrosome anchoring[1]. Knockout studies in mice have demonstrated that the absence of FNDC8 leads to male infertility due to aberrations in sperm morphology and defective spermatogenesis[1]. Its role outside of testicular development is not well characterized, and FNDC8 is not currently a known target for therapeutic intervention[2][3][6]. The gene is catalogued in major biological databases and is sometimes mentioned in high-throughput studies of cancer/biomarker gene expression, but direct links to disease other than infertility have not been established[2][3].

Other names

FNDC8Fibronectin type III domain containing 8DKFZp434H2215Fndc8 (mouse homolog)

Not applicable, as no drugs are known to interact with the protein.