Fibrosis-related gene expression pathways

"Fibrosis-related gene expression pathways" refers to the constellation of cellular signaling, transcriptional, and post-transcriptional mechanisms that regulate fibrogenesis—the pathological accumulation of extracellular matrix components such as collagen, fibronectin, and various glycoproteins leading to tissue scarring. Key pathways and molecules include: - TGF-β signaling: a central mediator that drives fibroblast activation and collagen synthesis. - PDGF signaling: vital for fibroblast proliferation and migration. - MAPK, PI3K-Akt, and ER stress/UPR: involved in cell survival, inflammation, and apoptosis in fibrotic microenvironments. - Integrin and protease-activated receptor signaling: modulate cell-matrix and cell-cell interactions, influencing inflammation and matrix remodeling. - Genes commonly upregulated in fibrosis: COL1A1, COL3A1, COL1A2 (collagens); SPP1 (Osteopontin); CTGF (Connective tissue growth factor); EFEMP2, FBLN5 (fibulin family); THBS2 (thrombospondin-2)[2][3][4]. These signaling networks are not unique to a particular organ but are found in lung, liver, heart, kidney, and other tissues undergoing pathological fibrosis. Rather than being a standard "therapeutic target," this term covers many possible targets; drug development focuses on inhibiting or modulating one or more of these molecular components[2][3][4][5][6]. **Key insights:** - "Fibrosis-related gene expression pathways" does *not* correspond to a single druggable target but an umbrella for numerous targets already under investigation. - Canonical targets within these pathways include TGF-β receptors, PDGF receptors, integrins, and key matrix regulators, each with their own gene/protein names and disease relevance. - As a label for structured target data, this entry is *incorrect*—it is too broad and should be broken down into the specific molecular targets within the pathway for accurate drug, biomarker, and mechanism mapping.

Other names

Fibrotic gene expression networksFibrosis-associated pathwaysFibrotic signaling pathwaysFibrosis transcriptomic signatures