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Fidgetin-like 2 (FL2)
- Target
- FL2
- Molecular classification
- Enzyme, Microtubule-severing ATPase
01
Overview
FL2, or Fidgetin-like 2, is a microtubule-severing enzyme that regulates cytoskeletal dynamics. It acts as a negative regulator of axon regeneration and cell migration by severing dynamic microtubules, particularly at the cell cortex and leading edge. Depletion of FL2 has shown promise in promoting nerve regeneration after injury and enhancing wound healing.
- Other names
- FIGNL2FIGL2
02
Mechanism of action
Microtubule severing
03
Biological functions
Negative regulation of axon regenerationSuppression of cell migrationCytoplasmic microtubule organizationMicrotubule severing
04
Disease associations
Nerve injuryWound healingErectile dysfunction post-prostatectomySkin injury
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