Filaggrin-2 (FLG2)

Filaggrin-2 is a large, S100 fused-type structural protein found in the granular keratinocytes of human skin, encoded by the *FLG2* gene[2]. Functionally, it is similar to filaggrin, mediating epidermal differentiation, cornification, and formation of the stratum corneum, which maintains the skin barrier. Filaggrin-2 undergoes proteolytic processing to provide free amino acids that contribute to natural moisturizing factors, regulate stratum corneum pH, and afford photoprotection. Mutations or reduced expression of *FLG2*, as seen in some atopic dermatitis patients, result in skin barrier impairment, increased sensitivity to UV radiation, abnormal cornification (parakeratosis), altered proteolytic processing of related proteins, and reduced quantities of protective amino acids[2]. Filaggrin-2's deficiency is linked to chronic skin diseases such as atopic dermatitis and persistent barrier dysfunction. It is one of several epidermal S100 fused-type proteins involved in skin health and disease.

Other names

Filaggrin-2FLG2IFPSFLG-2IfapsoriasinIntermediate filament-associated and psoriasis-susceptibility proteinPSS6filaggrin family member 2