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Filamenting temperature-sensitive mutant Z (FtsZ)

Target: FtsZ
Molecular classification: GTPase, Cytoskeletal protein

Overview

FtsZ is a highly conserved, essential protein in bacteria and archaea that plays a central role in cell division. It is considered the prokaryotic homolog of tubulin. FtsZ assembles into a dynamic ring structure at the future site of cytokinesis, known as the Z-ring, which serves as a scaffold and potentially generates constriction force. It is a target for antibacterial agents.

Other names: ftsZ

Mechanism of action

Inhibition of FtsZ polymerization

Biological functions

Cell divisionCytokinesisZ-ring formationSeptum formationCell wall synthesis regulation

Disease associations

Infection

Safety considerations

Specificity to bacterial FtsZ to avoid off-target effects

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