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Target intelligence / Profile preview
Filamentous Actin (F-actin)
- Target
- F-actin
- Molecular classification
- Cytoskeletal protein, Actin family, Structural protein
01
Overview
Filamentous actin (F-actin) is the polymerized form of actin, a fundamental component of the eukaryotic cytoskeleton. It forms a dynamic, double-helical structure that plays critical roles in cell shape, movement, and intracellular transport. F-actin provides mechanical support, serves as tracks for motor proteins, and participates in cytoskeletal rearrangements. Its polymerization/depolymerization is tightly regulated by actin-binding proteins. F-actin is a key therapeutic target, and its disruption is implicated in various diseases, including cancer and infections.
- Other names
- Actin filamentsF actin
02
Mechanism of action
Interference with actin polymerization/depolymerization dynamics
03
Biological functions
Cell shape maintenanceCell motilityMuscle contractionCytokinesisIntracellular transportPhagocytosisSignal transductionMechanical support
04
Disease associations
CancerInfectionCardiovascular diseaseNeurodegenerative diseaseOther (related to cytoskeletal dysfunction)
05
Safety considerations
Disruption of essential cellular processesPotential for off-target effects due to the ubiquitous nature of actin
06
Interacting drugs
Cytochalasans
2 more in the full profile.
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