Target intelligence / Profile preview

Bordetella pertussis Filamentous Hemagglutinin (FHA)

Target: FHA
Molecular classification: Adhesin, Surface-associated protein, Secreted protein

Overview

Filamentous hemagglutinin (FHA) is a large, cell surface-associated and secreted protein produced by the bacterium *Bordetella pertussis*, the causative agent of whooping cough. FHA functions primarily as an adhesin, facilitating bacterial attachment to host epithelial cells and contributing significantly to the organism’s virulence. It is secreted via the two-partner secretion (TPS) pathway and is a key antigen in acellular pertussis vaccines.

Other names: Filamentous hemagglutininFhaB precursorTpsA

Biological functions

Adherence to respiratory epithelial cellsColonizationImmune modulationImmune evasion

Disease associations

InfectionWhooping coughPersistence in lower respiratory tract

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