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Filamentous Hemagglutinin Protein (FHA)
- Target
- FHA
- Molecular classification
- Adhesin, Surface-associated protein, Secreted protein
01
Overview
Filamentous hemagglutinin (FHA) is a large, rod-shaped, highly immunogenic protein produced by Bordetella species, most notably Bordetella pertussis. FHA is both surface-associated and secreted by the bacteria and plays a critical role in bacterial adherence to host cells and in virulence. It mediates attachment to ciliated respiratory epithelial cells and macrophages through several binding domains, including a heparin-binding domain, a carbohydrate-recognition domain, and an RGD motif. FHA also modulates the host immune response, contributing to immunosuppression during infection. It is a key component of acellular pertussis vaccines.
- Other names
- FHA proteinfhaBFhaB precursor
02
Mechanism of action
Adhesion blocking, immune modulation interference
03
Biological functions
AdhesionImmune modulationColonization
04
Disease associations
InfectionWhooping coughRespiratory disease
05
Safety considerations
Potential for immunogenicity issues related to specific protein domainsLimited potential for adverse effects given its use in established vaccines
06
Interacting drugs
None
07
Biomarkers
Antibody response to FHA as a measure of vaccine efficacy
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