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Target intelligence / Profile preview
Filamentous Temperature-Sensitive Protein Z (FtsZ)
- Target
- FtsZ
- Molecular classification
- Tubulin superfamily, GTPase
01
Overview
Filamentous temperature-sensitive protein Z (FtsZ) is a highly conserved prokaryotic protein essential for bacterial cell division. It is a functional and structural homologue to eukaryotic tubulin, polymerizing in a GTP-dependent manner to form the Z-ring, which acts as a scaffold for recruiting other proteins involved in septum formation. FtsZ is a validated antibacterial drug target, with several inhibitors being developed to disrupt its function and combat antibiotic-resistant pathogens.
- Other names
- FtsZ proteinftsZ
02
Mechanism of action
Inhibition of FtsZ polymerization and/or GTPase activity, leading to disruption of Z-ring formation and bacterial cell division.
03
Biological functions
Cell divisionCytokinesisZ-ring formationSeptum formationGTP hydrolysis
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects due to structural similarity with eukaryotic tubulin (though sequence identity is low).
06
Interacting drugs
Phenylpropanoids (e.g., caffeic acid)
2 more in the full profile.
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