Filamin-A-interacting protein 1 (FILIP1)

Filamin-A-interacting protein 1 (FILIP1) is an actin-binding cytoskeletal regulatory protein encoded by the FILIP1 gene[4][5][6]. It binds filamin A and stimulates its degradation, which in turn regulates cytoskeletal structure essential for cell migration, particularly in the developing neocortex[1][3][5][6]. FILIP1 helps control neuronal polarity and the transition between multipolar and bipolar cell shapes, thus supporting proper arrangement and migration of neurons during brain development[1][3]. In muscle cells, FILIP1 functions as a dual-compartment protein, linking microtubules to myofibrils and helping assemble and stabilize these structures during differentiation; it also protects muscle cells from mechanical stress-induced damage[2]. Beyond the nervous system and muscle, FILIP1 expression and function have been implicated in various pathological conditions, including neurodevelopmental disorders, ulcerative colitis, and several cancers, where its altered expression correlates with prognosis or chemoresistance[1][5]. FILIP1 is not typically classified as a therapeutic target, and no drugs are known to interact with it directly[5][6].

Other names

FILIP1Filamin-A-interacting protein 1KIAA1275FILIPNMDFFLIP1

Not applicable; no drugs target FILIP1 directly. FILIP1 itself modulates protein degradation, migration, and cytoskeletal dynamics