Filamin B (FLNB)

Filamin B (FLNB) is a large cytoskeletal actin-binding protein encoded by the FLNB gene on chromosome 3p14.3. It organizes actin filaments into orthogonal networks, anchoring them to cellular membranes and participating in scaffolding for transmembrane receptors. FLNB is essential for intracellular signaling, mechanotransduction, and the regulation of cell structure, shape, and motility, being particularly important in chondrocyte biology and bone development; mutations are a major cause of several congenital skeletal malformation syndromes. Beyond structural roles, FLNB also regulates transcription and alternative splicing, and its dysregulation has been linked to altered cell death, proliferation, and metastasis in cancer. Currently, FLNB is not a direct target of any approved drugs but is a relevant biomarker in clinical genetics for specific skeletal dysplasias.

Other names

Filamin-BFLN1LFLN3TABPTAPFLN-BFh1Truncated ABPABP-278FH1ABP-280 homologActin-binding-like proteinBeta-filaminFilamin homolog 1Filamin-3Thyroid autoantigenTruncated actin-binding proteinLarsen syndrome 1LRS1SCTAOI

Not applicable, as there are currently no drugs known to target FLNB directly.