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"Filling" in clinical context refers to the *material or procedure used to restore tooth structure lost to decay, fracture, or wear*. Common filling materials include silver amalgam (which contains elemental mercury, silver, copper, and tin), composite resin, porcelain, and glass ionomer[1][2][3][6]. The process is entirely mechanical and structural, not involving biological interactions typical for drug targets. Dental fillings help repair and strengthen teeth, preventing further decay or damage[2][3]. While some materials—such as amalgam—raise safety discussions due to mercury content, there is no biological or molecular receptor involved[4]. The term "physical filling" may be a misinterpretation or mistaken entry—there is no molecule, protein, or receptor called "Physical filling," and it does not fit scientific conventions for therapeutic targets.
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