Target intelligence / Profile preview

FimH adhesin protein (FimH)

Target: FimH
Molecular classification: Adhesin, Lectin

Overview

FimH is a bacterial adhesin protein located at the tip of type 1 fimbriae in Escherichia coli and other Enterobacteriaceae. It mediates the initial attachment of bacteria to host cells by specifically binding to D-mannose residues on host tissues. This interaction is crucial for colonization and infection, particularly in urinary tract infections. It consists of a lectin domain (mannose-binding) and a pilin domain, connected by a short linker. FimH exhibits catch bond behavior, where binding affinity increases under mechanical shear stress.

Mechanism of action

Adhesion inhibition

Biological functions

AdhesionBacterial attachmentHost cell binding

Disease associations

Urinary tract infectionsInfection

Safety considerations

Potential for resistance developmentOff-target effects of inhibitors

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