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Target intelligence / Profile preview
Firre intergenic repeating RNA element (FIRRE)
- Target
- FIRRE
- Molecular classification
- Long non-coding RNA (lncRNA), Intergenic lncRNA
01
Overview
Firre intergenic repeating RNA element (FIRRE) is a long non-coding RNA (lncRNA) located on the X chromosome (chrX:131702650-131830643, hg38). FIRRE is not translated into protein, as shown by multiple protein-coding potential analyses. Its transcript coats chromosomes and is retained in the nucleus via interaction with heterogeneous nuclear ribonucleoprotein U (hnRNPU). FIRRE serves as a scaffold for chromatin organization—it mediates chromatin looping and recruits histone modifiers, anchoring the inactive X chromosome to the nucleolus and maintaining H3K27me3 repressive methylation. FIRRE is implicated in trans-chromosomal interactions and has documented roles in regulation of gene expression relevant to pluripotency, adipogenesis, and innate immunity by modulating mRNA stability. There are currently no direct drug interactions or established biomarker or safety data for FIRRE.
- Other names
- LINC01200functional intergenic repeating RNA elementfirre
02
Biological functions
Chromatin loopingHistone modifier recruitmentNuclear retention via hnRNPU interactionMaintenance of repressive chromatin (H3K27me3)Regulation of mRNA stabilityInvolvement in pluripotency and adipogenesis
03
Disease associations
Cancer (suggestive)Immunity/Inflammation (regulation of mRNA stability in innate immune responses)
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