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Target intelligence / Profile preview
FK506-binding protein 4 (FKBP52)
- Target
- FKBP52
- Molecular classification
- Immunophilin, Peptidyl-prolyl cis-trans isomerase, Chaperone
01
Overview
FK506-binding protein 4 (FKBP52) is an immunophilin family member with peptidyl-prolyl cis-trans isomerase (PPIase) activity. It functions as a molecular chaperone, interacting with heat shock proteins (Hsp90 and Hsp70) and steroid hormone receptors, influencing protein folding, trafficking, and signaling pathways. It is implicated in neuroprotection and regulation of microtubule dynamics. Recent research suggests its potential as a biomarker and therapeutic target in Alzheimer's disease.
- Other names
- FKBP4Peptidyl-prolyl cis-trans isomerase FKBP4PPIase FKBP4HSP-binding immunophilin
02
Mechanism of action
Peptidyl-prolyl cis-trans isomerase inhibition; co-chaperone activity impacting protein folding and stability.
03
Biological functions
Protein foldingCellular signalingApoptosis regulationTranscriptional controlSteroid hormone receptor signalingMicrotubule dynamics regulationNeuronal growth cone regulationOxidative stress protection
04
Disease associations
Alzheimer's disease
05
Interacting drugs
FK506 (tacrolimus)
1 more in the full profile.
06
Biomarkers
FKBP52 levels in Alzheimer's disease
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