Target intelligence / Profile preview

FKBP prolyl isomerase 1B pseudogene 1 (FKBP1BP1)

Target
FKBP1BP1
Molecular classification
Other, Pseudogene
01

Overview

FKBP prolyl isomerase 1B pseudogene 1 (FKBP1BP1) is classified as a pseudogene, specifically a nonfunctional DNA sequence that resembles the functional FKBP prolyl isomerase 1B (FKBP1B) gene. Pseudogenes generally do not encode functional proteins and lack therapeutic relevance, although some can play regulatory roles as RNAs. FKBP1BP1 is annotated in the human genome (chr14:41742639-41742963), but as a pseudogene, it does not serve as a drug target or have known direct biological or disease associations. No aliases or direct pathological links have been reported. FKBP1BP1 is not a functional gene but a pseudogene; it is similar in sequence to FKBP1B (which encodes a functional FK506-binding protein), but does not encode a functional protein. Pseudogenes are generally not considered therapeutic targets—they are "nonfunctional segments of DNA that resemble functional genes" and do not typically have protein products or mechanisms of action amenable to drug modulation. Most pseudogenes, including FKBP1BP1, do not have established aliases, interactors, or disease links; no clinical safety or biomarker relevance is described. FKBP1BP1 is distinct from FKBP1A and FKBP1B, which are functional members of the FKBP family, some of which (e.g., FKBP1A) have therapeutic relevance in immunosuppression. The pseudogene label classifies FKBP1BP1 as nonfunctional and of minimal biomedical importance under current knowledge.

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