FKBP prolyl isomerase 9 pseudogene 1 (FKBP9P1)

FKBP prolyl isomerase 9 pseudogene 1 (FKBP9P1) is classified as a long non-coding RNA pseudogene related to the FKBP family, but does not encode a functional protein. Recent studies implicate FKBP9P1 in the progression of head and neck squamous cell carcinoma, where its high expression correlates with increased cell proliferation, migration, invasion, and a poor patient prognosis. Mechanistically, FKBP9P1 appears to regulate cancer cell biology through effects on the PI3K/AKT signaling pathway, and silencing FKBP9P1 suppresses these tumorigenic phenotypes in vitro. This suggests FKBP9P1 may be a promising diagnostic and prognostic marker, as well as a potential molecular target for future therapeutics in oncology. Unlike classical FKBP family proteins, FKBP9P1 does not function as an enzyme, receptor, or protein chaperone, and there are no known direct chemical modulators. It is not a canonical therapeutic target but does function as a disease-associated regulatory lncRNA. Key limitations: FKBP9P1 is commonly mischaracterized as a protein, but is a non-coding RNA pseudogene; therapeutic targeting remains theoretical, with active research focused on its role in cancer biology rather than direct drug modulation.

Other names

Putative FK506-binding protein 9-like proteinFKBP9P1FKBP9LMGC20531FK506-binding protein 9-like protein pseudogene