FKBP prolyl isomerase family member 15 (FKBP15)

FKBP prolyl isomerase family member 15 (FKBP15) is a cytosolic protein encoded by the FKBP15 gene. It is predicted to enable actin-binding activity and has a domain structure consistent with FKBP-type peptidyl-prolyl isomerases, though it appears to be inactive as a PPIase in humans. FKBP15 is involved in the cytoskeletal organization of neuronal growth cones and participates in the transport of early endosomes at the interface of actin and microtubule based movement. While several members of the FKBP family play important roles in immunosuppression, protein folding, and cell signaling, FKBP15's exact mechanism and drug interactions remain less defined. Disorders associated with FKBP15 include hereditary spastic paraplegia, a neurodegenerative condition affecting motor neurons

Other names

FKBP15KIAA0674PPP1R76FKBP133

Null for FKBP15 specifically regarding known drug mechanisms, as there is no evidence it interacts directly with clinically used drugs. General FKBP mechanism (for other family members): Drug binding leading to immunosuppression via calcineurin inhibition