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Target intelligence / Profile preview
FKBP prolyl isomerase family member 6 (FKBP6)
- Target
- FKBP6
- Molecular classification
- Enzyme (immunophilin, peptidyl-prolyl cis-trans isomerase family), Chaperone (co-chaperone via HSP90 interaction), Other (immunoregulatory)
01
Overview
FKBP prolyl isomerase family member 6 (FKBP6) is a member of the FK506 binding protein (FKBP) family and functions as an immunophilin related to protein folding and trafficking[3]. Unlike some other FKBPs, FKBP6 is considered catalytically inactive as a peptidyl-prolyl cis-trans isomerase, though it shares the family’s structural domain[3]. FKBP6 has a critical role in spermatogenesis and maintenance of germline genome integrity through repression of transposable elements in germ cells, acting through the piRNA metabolic pathway and forming complexes with Piwi proteins for transposon silencing[3]. The gene is located in a region that can be deleted in Williams-Beuren syndrome, and its genetic defects are associated with specific forms of male infertility[3]. FKBP6 does not appear to be a direct therapeutic target, nor are drugs currently known to interact with it, but its loss-of-function or mutation is important in reproductive biology and genomic regulation.
- Other names
- FKBP6FKBP36Inactive peptidyl-prolyl cis-trans isomerase FKBP636 kDa FKBPFKBP-36FKBP-6PPIase FKBP6peptidylprolyl cis-trans isomerase FKBP6rotamaseimmunophilin FKBP36SPGF77
02
Mechanism of action
Not a direct drug target; no known mechanism of drug action on FKBP6
03
Biological functions
SpermatogenesisProtein foldingTraffickingImmunoregulationTransposon repression (via piRNA pathway)Secondary piRNA biogenesisMaintenance of germline genome integrity
04
Disease associations
Male infertility (including Spermatogenic Failure 77)Association with Williams-Beuren syndrome (through gene deletion)Other
05
Safety considerations
None established for therapeutic modulationdeletion or inactivation may be associated with infertility and genomic instability
06
Biomarkers
Mutation or presence of FKBP6 may be used in male infertility (Spermatogenic Failure 77 diagnosis)
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