Flavonoid-sensitive antioxidant pathways

The "flavonoid-sensitive antioxidant pathways" encompass cellular mechanisms modulated by flavonoids, a large class of plant-derived polyphenols, which protect against oxidative stress through direct free radical scavenging, chelation of redox-active metals, modulation of gene expression (especially via the Nrf2 pathway), and upregulation of endogenous antioxidant defenses. These pathways are implicated in the prevention or mitigation of chronic diseases including cancer, cardiovascular disease, and neurodegeneration, as well as the regulation of inflammation and apoptosis. Flavonoids themselves do not target a single molecule, but instead exert their effects through a network of interacting antioxidant proteins, transcription factors, and regulatory enzymes[1][2][3][4].

Other names

Flavonoid-dependent antioxidant mechanismsFlavonoid-regulated oxidative stress pathwaysFlavonoid-modulated cellular antioxidant response

Direct scavenging of free radicals (hydrogen atom transfer, single electron transfer, etc.); activation of Nrf2-Keap1-ARE pathway (upregulation of antioxidant gene expression); chelation of transition metals; inhibition of pro-oxidant enzymes; restoration/regeneration of other antioxidants (vitamin C/E).