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Flea Salivary Allergens
- Molecular classification
- Protein, Allergen, Enzyme
01
Overview
Flea salivary allergens are a complex mixture of proteins and other compounds found in flea saliva that trigger allergic reactions in sensitive hosts. These allergens induce Type I and Type IV hypersensitivity reactions, leading to flea allergy dermatitis (FAD) in animals and localized or systemic allergic reactions in humans. The primary immunoglobulin involved is IgE, leading to mast cell degranulation and histamine release.
- Other names
- Flea allergenFlea saliva antigensFlea salivary proteins
02
Mechanism of action
Drugs work by eliminating fleas, reducing inflammation, or modulating the immune response to flea saliva antigens.
03
Biological functions
Induction of hypersensitivityImmune response elicitationMast cell activationHistamine release
04
Disease associations
Flea Allergy Dermatitis (FAD)Allergic reactions to flea bites
05
Safety considerations
Risk of secondary infections due to scratchingAdverse reactions to anti-inflammatory or immunomodulatory drugs
06
Interacting drugs
Anti-inflammatory drugs
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