Flotillin-2 (FLOT2)

Flotillin-2 is a membrane-associated scaffolding protein of the SPFH superfamily, functioning as a principal component of lipid raft microdomains. It is ubiquitously expressed in mammalian cells and plays a critical role in organizing multiprotein complexes at the plasma membrane and endomembranes. Flotillin-2, often together with flotillin-1, facilitates clathrin-independent endocytosis, cell signaling, and protein trafficking by forming large oligomeric complexes—sometimes described as basket- or cage-like structures—that isolate and coordinate localized biochemical processes. Its membrane attachment is regulated through *N*-myristoylation and *S*-palmitoylation, contributing to its association with cholesterol- and sphingolipid-rich raft domains. Flotillin-2 is implicated in cancer progression, neurodegenerative diseases, and possibly immunological and infectious pathologies, largely owing to its role in membrane dynamics, signaling, and vesicular transport.

Other names

Flotillin-2FLOT2ESA1M17S1ESAECS-1ECS1Epidermal surface antigenMembrane component chromosome 17 surface marker 1Flotillin 2 (epidermal surface antigen 1)membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1)

Not directly targeted pharmacologically; proposed mechanisms involve disruption of flotillin-2 oligomerization or membrane association to block its scaffolding function (hypothetical, preclinical context).