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Flt3-interacting zinc finger protein 1 (FIZ1)

Target: FIZ1
Molecular classification: Transcription factor, Zinc finger protein

Overview

Flt3-interacting zinc finger protein 1 (FIZ1) is a zinc finger-containing transcription factor that interacts with the cytoplasmic catalytic domain of FLT3 (Fms-like tyrosine kinase 3) in a kinase-independent manner following receptor stimulation. It is suggested to act as a transcriptional repressor of NRL (neural retina leucine zipper) function in photoreceptors, but does not appear to affect CRX-mediated transactivation. FIZ1 may play a role in retinal development and maintenance, but its precise functions and disease associations remain under-characterized in current literature. There is no evidence it is a direct therapeutic target, nor are there approved drugs or established safety concerns related to FIZ1 in humans.

Other names: FIZ1ZNF798FLJ14768Zinc finger protein 798flt3-interacting zinc finger protein 1

Biological functions

Transcriptional repression (particularly of NRL in photoreceptors)protein-protein interaction via receptor tyrosine kinase bindingpotential regulation of gene expression in retinal development

Disease associations

Other (no strong evidence for direct roles in major disease classes such as cancer, inflammation, etc.; possibly retinal function or development)

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