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Target intelligence / Profile preview
FLT3 proto-oncogene (FLT3)
- Target
- FLT3
- Molecular classification
- Receptor, Enzyme, Receptor tyrosine kinase, Class III receptor tyrosine kinase
01
Overview
FLT3 (fms-like tyrosine kinase 3) is a receptor tyrosine kinase that plays a crucial role in the regulation of hematopoiesis. It is expressed on hematopoietic progenitor cells and is essential for their proliferation, differentiation, and survival. Mutations or overexpression of FLT3 are frequently observed in acute myeloid leukemia (AML) and are associated with poor prognosis. FLT3 is a validated target for small molecule inhibitors, which are used clinically to treat AML patients harboring activating mutations.
- Other names
- fms-like tyrosine kinase 3CD135fetal liver kinase-2Flk2receptor-type tyrosine-protein kinase FLT3
02
Mechanism of action
Small molecule tyrosine kinase inhibitors
03
Biological functions
Signal transductionCell proliferationCell differentiationCell survivalHematopoiesis regulationImmune system development
04
Disease associations
CancerAcute Myeloid Leukemia (AML)Acute Lymphoblastic Leukemia (ALL)Myelodysplastic Syndrome
05
Safety considerations
Treatment failureRelapseWorse outcomesDrug resistance
06
Interacting drugs
Midostaurin
1 more in the full profile.
07
Biomarkers
FLT3 mutations (ITD, TKD)FLT3 expression level
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