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Fludarabine
- Molecular classification
- Purine nucleoside analog, Antimetabolite
01
Overview
Fludarabine is a small molecule chemotherapeutic drug classified as a purine nucleoside analog and antimetabolite[3][5][8]. It is not a receptor, enzyme, transporter, or endogenous protein target, but rather a compound that is structurally similar to adenosine and interferes with DNA replication and repair by inhibiting enzymes such as DNA polymerase, ribonucleotide reductase, and DNA primase[1][3][5]. It is used to treat cancers of the blood, notably chronic lymphocytic leukemia, via cytotoxic effects on rapidly dividing cells. The identification of "Fludarabine" as a target is incorrect, as it refers to a drug and not a molecular target or receptor.
- Other names
- FludarabineF-Ara-A2-Fluoro Ara-A9-beta-D-Arabinofuranosyl-2-fluoroadenineFludarabinaFludarabinum
02
Mechanism of action
Fludarabine interferes with DNA replication and repair by inhibiting enzymes such as DNA polymerase, ribonucleotide reductase, and DNA primase.
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