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Target intelligence / Profile preview
Fludarabine Phosphate (Prodrug Activation)
- Molecular classification
- Prodrug, Purine analog
01
Overview
Fludarabine phosphate is a water-soluble prodrug used in the treatment of hematologic malignancies. It is converted to its active form intracellularly, which inhibits DNA synthesis and induces apoptosis in cancer cells.
- Other names
- 2-fluoro-ara-A prodrugF-ara-A prodrugFludara
02
Mechanism of action
Fludarabine phosphate is a prodrug that is dephosphorylated to 2-fluoro-ara-A (F-ara-A), which is then phosphorylated to the active metabolite 2-fluoro-ara-ATP (F-ara-ATP). F-ara-ATP inhibits DNA polymerase alpha, ribonucleotide reductase, DNA primase, and DNA ligase, and is incorporated into DNA, causing chain termination.
03
Biological functions
DNA synthesis inhibitionApoptosis inductionAntineoplastic activity
04
Disease associations
Cancer
05
Safety considerations
MyelosuppressionOpportunistic infectionsTumor lysis syndrome
06
Interacting drugs
Fludarabine phosphate
1 more in the full profile.
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