Target intelligence / Profile preview

Fluid volume overload

Overview

Fluid volume overload, also known as hypervolemia or fluid overload, is an increase in total body fluid, often manifesting as expansion of the extracellular fluid compartment and leading to symptoms such as edema, weight gain, and pulmonary congestion. It typically occurs secondary to diseases like heart failure, kidney failure, nephrotic syndrome, or cirrhosis, and is associated with complications in multiple organ systems due to impaired fluid regulation and excretion.

Other names: Fluid overloadHypervolemiaVolume overload

Disease associations

Cardiovascular diseaseKidney failureLiver diseaseOther

Safety considerations

Pulmonary edemaRespiratory failureElevated blood pressureWorsened heart failureOrgan dysfunction

Biomarkers

Weight gainEdemaPositive fluid balanceElevated central venous pressureReduced hematocritPulmonary edemaAltered electrolytes

Beyond the preview

Go deeper on Fluid volume overload.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Fluid volume overload.

Explore the full profile