Fluke Beta-Tubulin (β-tubulin)

Fluke β-tubulin is a beta subunit of the tubulin protein found in parasitic flukes, such as *Fasciola hepatica*. It forms heterodimers with α-tubulin to assemble into microtubules, which are crucial for cell structure, intracellular transport, and cell division. Different β-tubulin isotypes exist and are expressed in specific tissues and life cycle stages. It is a primary target of benzimidazole anthelmintics. Mutations in key residues involved in drug binding can confer drug resistance.

Other names

Fasciola hepatica β-tubulinF. hep-β-tubLiver Fluke Beta Tubulinβ-tubulin

Inhibition of microtubule polymerization, leading to disruption of cell division and intracellular transport.