Fluoridated hydroxyapatite (FHA)

Fluoridated hydroxyapatite is a chemically modified form of the primary mineral component of human tooth enamel, created when fluoride ions substitute for hydroxyl groups within the hydroxyapatite crystal lattice (dentalcare.com). This substitution results in a more stable and less soluble mineral structure, which significantly enhances the enamel's resistance to acid-induced demineralization by lowering its critical pH from approximately 5.5 to 4.5 (greatoralhealth.com). In clinical practice, the formation of fluoridated hydroxyapatite is the primary objective of fluoride therapy, which is the cornerstone of modern preventive dentistry (cfp.ca). By promoting the remineralization of early carious lesions and providing a protective barrier against bacterial acids, it plays a vital role in preventing and arresting dental caries (nih.gov). Beyond caries prevention, fluoridated hydroxyapatite is also relevant in managing enamel erosion and dentin hypersensitivity (patsnap.com). However, excessive fluoride exposure during tooth development can lead to dental fluorosis, highlighting the need for controlled therapeutic application (utahpediatricdentists.com).

Other names

FluorapatiteFluorhydroxyapatiteFluoridated hydroxyapatiteFHAFAp

Fluoride ions substitute for hydroxyl groups in the hydroxyapatite crystal lattice to form fluoridated hydroxyapatite, which has a lower critical pH and higher acid resistance. This process promotes the remineralization of early carious lesions and inhibits the demineralization of sound enamel (dentalcare.com, nih.gov).