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Fluorodeoxyglucose (FDG)
- Target
- FDG
- Molecular classification
- Glucose analog, Radiopharmaceutical
01
Overview
Fluorodeoxyglucose (FDG) is a radiopharmaceutical used in positron emission tomography (PET) imaging. It is an analog of glucose where one hydroxyl group is replaced by the radionuclide fluorine-18. FDG is used to visualize tissues with high glucose uptake, such as tumors, areas of inflammation, and metabolically active brain regions. It is the most commonly used PET tracer.
- Other names
- 18F-fluorodeoxyglucose2-deoxy-2-(18F)fluoro-D-glucoseFluoro-D-glucose
02
Mechanism of action
FDG is taken up by cells similarly to glucose but is trapped intracellularly after phosphorylation by hexokinase. The accumulation of FDG reflects the glucose metabolic activity of the tissue. The 18F isotope emits positrons, which are detected by PET scanners to create images of FDG distribution.
03
Biological functions
Glucose metabolism tracerPositron emission tomography imaging agent
04
Disease associations
Cancer imagingCardiac imagingNeurological imaging
05
Safety considerations
Exposure to ionizing radiationAllergic reactions (rare)Pregnancy and breastfeeding considerations
06
Biomarkers
FDG uptake as a measure of glucose metabolismStandardized Uptake Value (SUV)
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