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Fluorouracil Metabolite Incorporation into DNA

Molecular classification: Other

Overview

Fluorouracil metabolite incorporation into DNA refers specifically to the process where active metabolites like FdUTP are integrated by cellular polymerases during replication. This disrupts genome integrity through abnormal base pairing and subsequent repair attempts—contributing significantly but not exclusively to the anticancer activity profile seen with fluoropyrimidine drugs like 5-FU.

Mechanism of action

Incorporation of fluorouracil metabolites into DNA leading to strand breaks and DNA damage response activation.

Biological functions

DNA damageApoptosisCell death

Disease associations

Cancer

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CytotoxicityMutagenesis

Interacting drugs

Fluorouracil

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