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FLYWCH-type zinc finger-containing protein 1 (FLYWCH1)
- Target
- FLYWCH1
- Molecular classification
- Transcription factor, C2H2-type zinc finger protein, FLYWCH zinc finger domain protein
01
Overview
FLYWCH-type zinc finger-containing protein 1 (FLYWCH1) is a nuclear transcription factor belonging to the Cys2-His2 (C2H2)-type zinc finger protein family, containing a tandem array of five FLYWCH-type zinc finger motifs and a nuclear localization signal[1][4]. It is mainly localized in the nuclear bodies and nucleoplasm, and is involved in regulating the DNA damage response, specifically by modulating H2AX phosphorylation independently of ATM, implicating a novel signaling axis in DNA repair processes[1]. FLYWCH1 affects key cell behaviors, such as proliferation, migration, and attachment, and shows altered expression under DNA damage stress and anticancer drug exposure (e.g., cisplatin)[1]. While FLYWCH1 itself is not directly targeted by drugs nor considered a canonical therapeutic receptor or enzyme, it may modulate sensitivity to DNA-damaging agents and is under investigation for its regulatory role in cancer biology[1][6].
- Other names
- FLYWCH-type zinc finger 1KIAA1552DKFZp761A132FLYWCH1
02
Biological functions
DNA damage responseDNA repair signalingRegulation of cell proliferationRegulation of cell migrationRegulation of cell–cell attachmentPotential involvement in chromatin organization
03
Disease associations
Cancer (notably colorectal cancer)Potential, but not established, roles in platinum drug resistance
04
Biomarkers
γH2AX (colocalized; DNA damage marker)
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