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Target intelligence / Profile preview
Fms-like tyrosine kinase 3 ligand (FLT3LG)
- Target
- FLT3LG
- Molecular classification
- Hematopoietic cytokine, Growth factor
01
Overview
Fms-like tyrosine kinase 3 ligand (FLT3LG) is a cytokine that regulates hematopoiesis by controlling the proliferation, differentiation, and survival of early hematopoietic progenitor cells. It binds to its receptor, FLT3, on multipotent progenitor cells and common lymphoid progenitors, stimulating dendritic cell growth and increasing the numbers of immune cells. Dysregulation of FLT3LG and its receptor, FLT3, is implicated in hematological malignancies like AML and autoimmune diseases.
- Other names
- FLT3LFL
02
Mechanism of action
Binds and activates FMS-like tyrosine kinase 3 (FLT3/CD135), leading to receptor dimerization and autophosphorylation, initiating downstream signaling cascades (STAT5a, ERK1/2, PI3K) to promote cell survival, proliferation, and differentiation.
03
Biological functions
Hematopoiesis regulationDendritic cell developmentLymphocyte expansionImmune cell proliferationStem cell mobilization
04
Disease associations
Hematological Malignancies (AML)Autoimmune Diseases (Rheumatoid Arthritis)
05
Safety considerations
Overactivity or activating mutations in FLT3 are implicated in AML and associated with poor prognosis.
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