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Target intelligence / Profile preview
Fms-like Tyrosine Kinase 3 Ligand Receptor (FLT3)
- Target
- FLT3
- Molecular classification
- Receptor Tyrosine Kinase, Class III Receptor Tyrosine Kinase
01
Overview
FLT3 (Fms-like tyrosine kinase 3), also known as CD135, is a receptor tyrosine kinase primarily expressed on hematopoietic progenitor cells. It plays a critical role in the regulation of survival, proliferation, and differentiation of hematopoietic stem and progenitor cells. Mutations in FLT3 are common in acute myeloid leukemia (AML), leading to constitutive activation and aggressive disease. FLT3 has become an important therapeutic target, with several small-molecule inhibitors developed for clinical use, although resistance mechanisms limit long-term efficacy.
- Other names
- CD135Flt3 receptor
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Signal transductionCell survivalCell proliferationCell differentiationHematopoiesisImmune response
04
Disease associations
Acute Myeloid Leukemia (AML)Acute Lymphoblastic LeukemiaMyelodysplastic SyndromeRheumatoid ArthritisCancer
05
Safety considerations
Resistance to FLT3 inhibitorsLimited long-term efficacySpecific subsets respond durably to targeted therapy
06
Interacting drugs
FLT3 inhibitors
07
Biomarkers
FLT3 mutations (ITD, point mutations)
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