FMS-like tyrosine kinase 3 receptor (FLT3)

FMS-like tyrosine kinase 3 receptor (FLT3), also known as CD135, FLK-2, and STK-1, is a class III receptor tyrosine kinase that plays a crucial role in hematopoiesis. It is primarily expressed on immature hematopoietic progenitor cells and regulates their proliferation, survival, and differentiation. FLT3 is activated by its ligand, FLT3 ligand (FLT3L), leading to autophosphorylation and downstream signaling cascades. Mutations in FLT3, particularly internal tandem duplications (ITD) and tyrosine kinase domain mutations, are frequently found in acute myeloid leukemia (AML) and contribute to uncontrolled proliferation. FLT3 inhibitors have been developed as therapeutic agents for AML, but resistance often emerges during treatment. Dysregulation of FLT3 can also contribute to autoimmune diseases.

Other names

CD135FLK-2STK-1fetal liver kinase-2human stem cell kinase-1

Inhibition of FLT3 tyrosine kinase activity