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Target intelligence / Profile preview
FMS-like tyrosine kinase receptor (FMS)
- Target
- FMS
- Molecular classification
- Receptor, Tyrosine Kinase Receptor, CSF1/PDGF receptor family
01
Overview
FMS-like tyrosine kinase receptor (CSF1R), also known as FMS or CD115, is a tyrosine kinase transmembrane receptor belonging to the CSF1/PDGF receptor family. It plays a crucial role in the development and function of macrophages and other myeloid cells. Activation by its ligands, colony-stimulating factor 1 (CSF-1) and interleukin-34 (IL-34), promotes cell survival, differentiation, and migration. It is implicated in various diseases, including cancers and inflammatory conditions.
- Other names
- CSF1RCD115
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Cell survivalCell differentiationCell migrationMacrophage developmentMyeloid cell development
04
Disease associations
Myeloid malignanciesCancersInflammatory conditions
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