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Target intelligence / Profile preview
Fms-like tyrosine kinase receptor 1 (FLT1)
- Target
- FLT1
- Molecular classification
- Receptor Tyrosine Kinase
01
Overview
Fms-like tyrosine kinase receptor 1 (FLT1), also known as vascular endothelial growth factor receptor 1 (VEGFR-1), is a member of the receptor tyrosine kinase family. It functions primarily as a cell-surface receptor for several key angiogenic factors, including VEGF-A, VEGF-B, and placental growth factor (PlGF). FLT1 plays an essential role in embryonic vasculature development and regulation of blood vessel formation. The soluble form sFlt‑1 acts as an antiangiogenic molecule by binding free VEGF-A and PlGF in circulation, reducing their availability to activate membrane-bound receptors on endothelial cells. Abnormal expression or function of FLT‑1/sFlt‑1 has been implicated in several pathological conditions including preeclampsia, cardiovascular disease, and cancer.
- Other names
- Vascular endothelial growth factor receptor-1VEGFR-1
02
Mechanism of action
Tyrosine kinase inhibition (for drugs targeting the kinase domain); VEGF/PlGF sequestration (for sFlt-1 mimetics)
03
Biological functions
AngiogenesisVascular permeabilityEndothelial cell proliferationSignal transduction
04
Disease associations
PreeclampsiaCardiovascular diseaseCancer
05
Safety considerations
Potential for off-target effects due to promiscuity of receptor tyrosine kinasesDisruption of normal angiogenic processesCardiac remodelingEndothelial dysfunction
06
Biomarkers
sFlt-1 levels (in preeclampsia)FLT1 genetic variations (in cancer prognosis)
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