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Target intelligence / Profile preview
Fms-like tyrosine kinase receptor 4 (VEGFR-3)
- Target
- VEGFR-3
- Molecular classification
- Type IV Receptor Tyrosine Kinase (RTK), Vascular Endothelial Growth Factor (VEGF) receptor family, Receptor, Enzyme
01
Overview
Fms-like tyrosine kinase receptor 4 (FLT4), also known as VEGFR-3, is a receptor tyrosine kinase critical for lymphangiogenesis. It binds primarily to VEGF-C and VEGF-D and plays a key role in lymphatic vessel development and maintenance. It is implicated in diseases related to abnormal lymphangiogenesis, including lymphedema and tumor metastasis, making it a potential therapeutic target.
- Other names
- FLT4PCLvascular endothelial growth factor receptor-3fms related tyrosine kinase IVVEGFR-IIILMPH1Avascular endothelial growth factor receptor III
02
Mechanism of action
Ligand binding induces dimerization, activating the intracellular tyrosine kinase domain via autophosphorylation, initiating downstream signaling pathways.
03
Biological functions
LymphangiogenesisSignal transductionCell proliferationCell migrationCell survival
04
Disease associations
LymphedemaTumor metastasisVascular malformationsLymphangiomaCancer
05
Safety considerations
Modulating lymphangiogenesis can have complex effects on tumor metastasis and immune responses.
06
Biomarkers
Lymphatic vessel marker
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